Stephen Rees's blog

Thoughts about the relationships between transport and the urban area it serves

Uber Cannot Deliver

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This has been one of my continuing personal campaigns – to try and persuade the gullible that Uber is not now, nor ever has been, viable.

If you are on Twitter you ought to be following Cory Doctorow ( @doctorow) for a vast number of reasons but not least for information like this

“The only reason it [Uber] exists is that the Saudi royals decreed that they would diversify their income, and gave Softbank an unlimited investment budget. Softbank backs companies that it thinks can monopolize a sector, allows them to lose money for years – decades! Softbank assigns its companies absurd, unsupportable valuations, in the hopes of scaring off competitors. If the monopoly rents never materialize, Softbank flogs the company to rubes who were wowed by those sky-high valuations. That’s the Uber story.”

I did not know that. The reason I left the BC Green Party was that then Leader Andrew Weaver’s very personal commitment to getting Uber service in Vancouver. He had been inconvenienced at YVR one evening waiting for a taxi. So he used his leverage to get the market in BC broken open after years of successful opposition to an idea even dafter than Site C – which Weaver also implicitly supported by propping up the NDP.

So Cory recommends you to follow Hubert Horan. “40 years of experience in the management and regulation of transportation companies (primarily airlines). Horan has no financial links with any urban car service industry competitors, investors or regulators, or any firms that work on behalf of industry participants.”

Here is but a short excerpt of what Horan has to say at the link given above:

“Nothing has happened to change the fact that after ten years, riders have always been fundamentally unwilling to pay prices that would cover Uber’s actual costs, that Uber was always less efficient than the traditional taxis it drove out of business, that its only “efficiency improvement” was to push driver compensation to minimum wage levels, and that its growth depended entirely on unsustainable predatory subsidies.

But if anyone still thought that Uber could somehow magically reverse its multi-billion dollar losses, the coronavirus should have put their fantasies totally to rest. The coronavirus has crushed the major drivers of urban car services demand, including business travel and discretionary urban entertainment (clubs, restaurants, etc.). Their customers remain highly concerned about the health risks of all forms of public transportation.”

If you are at all concerned about the future of transportation in our region – or any other – you really need to go read the rest of that. And add to that Uber Eats is now wrecking the business of restaurants that managed to get through the Covid19 shut down.

Written by Stephen Rees

August 10, 2020 at 7:29 pm

Posted in Transportation

Tagged with

“Miracle in the Desert”

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Ariel photo of the Salton Sea from the south
from Wikipedia CC BY-SA 4.0
File:SaltonSeaArielFromSouth.jpg
Created: 31 January 2012

I get offered all sorts of things by email. This time I was offered a “Press Screener” – access to a video on line that will become available soon. I get to write about it in the hopes that people will spread the word about the upcoming release.

This is an excerpt from the email which lead me to ask for access to the video

“…documentary release of filmmaker Greg Bassenian (“CSI: Miami”) eye-opening award-winning documentary Miracle in the Desert: The Rise and Fall of the Salton Sea,” which lays bare the startling environmental disaster that is the Salton Sea in California’s coveted Coachella valley.  Charting the Salton Sea’s creation in 1905 to the current devastating environmental crisis that it faces today, this harrowing journey takes the viewer into the toxic dust. As the largest lake in California begins to dry, millions of lives are in danger as clouds of toxic dust threaten the health of millions of Californians. … Bassenian’s  new documentary carefully plots the course of economic growth that sprouted a shimmering desert riviera laden with costly construction challenges developing into the perfect storm – creating an unstable ecosystem that now lays to waste the health of the Coachella Valley’s community as both local and federal governments look to pass the cost of fixing things onto someone other than themselves. This riveting investigative documentary will be released by Gravitas Ventures, a Red Arrow Studios company across North America on all VOD/Digital & Blu-Ray/DVD platforms beginning on September 22nd, 2020.”

I was aware that the water from the Colorado River no longer reaches the sea. What I did not know was that this was the result of some turn of the century real estate speculation based on the idea of making the desert bloom. It actually went badly wrong from the start. Both due to the unpredictable nature of severe weather events but also due to some remarkable ignorance on the way that rivers work. The idea to build a canal to tap into the massive waterflow of the Colorado just south of the Mexican border and send it back north to a desert a couple hundred feet below sea level seem an attractive proposition. But the notion that the canal would have to deal with a massive quantity of silt didn’t seem to occur to the promoters. Or the need for the diversion to be able to cope with flash floods when the river level rose.

Map of the Salton Sea drainage area
source: wikipedia

Far too much water turns out to be as big a problem as not nearly enough. And in Southern California where the major cities have been growing rapidly and the people there demanding more water as a result seems to have run counter to any idea that having created California’s largest lake, there could be dire consequences from not looking after it properly. Or at all.

Much of the movie is about the failure of the California state government doing anything effective. They have made many plans. There have been plenty of surveys. There has been no real action of any kind – other than trying to persuade farmers who were encouraged to move to the Coachella and Imperial valleys with the promise of irrigation to give up farming all together.

The big, immediate issue is the health of the population. Obviously the impacts are currently greatest locally but the potential problem is going to cover a much wider area, including those large new populations mentioned above. Indeed drying up of lake beds producing air quality problems with widespread health impacts is not new in California. On the other hand while politicians need to be seen to be concerned about public health, as we currently see with COVID, that doesn’t mean that they feel they have to do very much about it. Most Americans are still on their own, or at the mercy of insurance companies, when it comes to healthcare costs.

When I watched the video I was actually quite pleased that there was no mention of the current crises. I don’t think the words COVID or Trump occurred once. The feds do get the odd nod here and there but overwhelmingly the blame is being directed at Sacramento, the state capital. No individual politicians at State level are mentioned, though some local ones are very compelling in their on screen remarks. No political party is mentioned either. In fact the real surprise is how positive so many of the locals are that there are solutions that will work and will cost far less than doing nothing.

I highly recommend looking out for this video on your preferred streaming media source, and I hope that if you are in Southern California – or know people there – that this documentary will encourage you to consider what actions you can take to influence how the decision makers can be made to actually do their jobs for a change. Because a miracle is certainly needed

The featured image for this blog post also comes from Wikipedia
Samboy – I took a picture from the window of an airplane I was on”

Ariel photo of the Salton Sea from the south

  • CC BY-SA 4.0
  • File:SaltonSeaArielFromSouth.jpg
  • Created: 31 January 2012

Written by Stephen Rees

August 9, 2020 at 3:22 pm

Posted in Environment

Tagged with , ,

The Airport Lounge

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I tweeted today in response to a Tweet from YVR Airport who are celebrating their 89th birthday.

“Every time I travel through YVR airport I compare it to all the other airports I have used. YVR sets a standard which most fail to equal, and none exceeds. We recently had a complimentary pass for a lounge. In YVR we didn’t need it. Where we had a layover it wasn’t open!”

The tweet limit still means it does not really tell what I think is a story worth expanding. Elsewhere I have written about our trip in January to New Orleans. We did not manage to get a direct flight but had to switch from WestJet to Delta at Los Angeles.

VanCity had recently persuaded me to upgrade my VISA card and one of the sweeteners offered was airport lounge access. It turned out to be complimentary for the first occasion only. Since you have to get to the airport early for the lengthy (and completely unnecessary) “security” check there is usually at least an hour to waste once through the interrogations and interference. At YVR the US departures area is spacious, well laid out and actually quite interesting. I usually enjoy just wandering around and taking pictures. Since we had an early morning departure we would have stopped at Starbucks for coffee and either bran muffins or oatmeal or something equally “healthy”.

But since we had this voucher we went to the lounge. The breakfast on offer looked very much like the standard US hotel complimentary in the lobby type of thing. And in a very similar atmosphere. The wifi is free all over YVR anyway, so the lounge is not any different. You are just a bit further away from the gates and with only a view into the terminal. And a rather intrusive tv with the morning news – again just like the gate area. The fee I would now have to pay for subsequent visits would not be much different to what I would pay at Starbucks – or the restaurant at other times of day.

https://www.flickr.com/photos/stephen_rees/49461276967/

The connection at LAX to the flight to MSY (as NOLA is rendered in airport code) meant changing terminals by bus across the apron. Delta’s terminal is way too small and too darn crowded, but there was a lunch counter right next to our gate and they served craft beer. We had just enough time to eat lunch before our flight was called to start boarding.

On the way back, the story was different. The lounge we might have used was in the wrong terminal i.e. the one we arrived in not the one we left from. And anyway was closed to people with my kind of pass except in the early morning. The terminal used by WestJet was even nastier than that for Delta – and the choice of eating places was fast food or nothing. The noise level was atrocious. I was feeling a little under the weather – it turned out to be the ‘flu (not COVID19) – and I really wanted somewhere peaceful. At Amsterdam they have an art gallery and a library, both with comfy chairs. LAX was more like McDonalds on a midterm break. And were were there for three hours.

Worst of all, there was no working free wifi, and even the departure screens were hidden away behind a staircase. The well placed screens were only for commercials – the same ones for hours on a short rotation.

To be fair the Delta terminal is being enlarged and physically connected so that the need for a bus ride will be eliminated. I do not know what they plan for lounges and right now it seems to be unlikely we will be needing them in any foreseeable future. But at that time I would have been very much happier if my imposed wait could have been in YVR or an airport built to that standard than LAX. It was somewhat better than Kansas City, where Frontier had once required me to spend all day. But that isn’t saying much.

On the whole I have not felt especially constrained by the current travel restrictions and I am in no hurry to go very far again.

Written by Stephen Rees

July 22, 2020 at 4:08 pm

Posted in Air Travel

An Expected Disappointment

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Today I signed two petitions. One to divest the Canada Pension Plan from fossil fuels, the other a letter to the Environment Minister to require an environmental assessment of a massive coal mine expansion proposed for Alberta.

Then a news release arrived which I am copying in full below from Environmental Defence Canada which deplores the latest shortfall in the Trudeau government’s lacklustre efforts to meet the challenges of climate change and recovery from the Covid shut down. There has already been a reckoning of how little has been done for a Green New Deal type recovery here and how much thrown at the fossil fuel corporations, (“Canada has funnelled at least $11.86 BILLION to fossils in recent months, while directing only $222.78 million to clean energy”) so this latest failure to perform comes as no surprise. But it still makes me angry.

Environment and Climate Change Canada released their much-anticipated Strategic Assessment of Climate Change today. Copied below (and linked here) is our press release with our reaction. Please don’t hesitate to reach out for further clarification or questions. 


For Immediate Release: July 16, 2020

NEWS RELEASE: Federal government fails to deliver on promise to align infrastructure reviews with climate commitments

Just months after surprising withdrawal of Teck’s tar sands mine application, government wastes best chance to reconcile project decisions with commitment to become net-zero by 2050

Ottawa, Ont. – Today, the government missed the opportunity to implement a critical tool to achieving our climate targets: a climate test on new infrastructure. Public policy experts had hoped that with the introduction of the new Impact Assessment Act (Bill C-69), which requires that project reviews consider whether the impacts help or hinder Canada in achieving its climate commitments, Canada could get on track to doing its part to ensure a climate-safe future. The policy announced today falls short of ensuring this will happen

“The government has just made it harder for Canada to get on the right pathway to reach our target of becoming net-neutral by 2050,” said Julia Levin, Climate and Energy Program Manager at Environmental Defence. “It is inconsistent to commit to a green recovery and serious climate action while simultaneously failing to put into place a mechanism to ensure that only projects that are consistent with those goals are built. When it comes to addressing the climate emergency – especially when we’re not on track to meet our targets – we need to be using every tool in the toolbox.”

Environmental assessments in Canada have long failed to ensure that project approvals are consistent with a climate-safe future. Global fossil fuel companies are planning to produce about 120% more fossil fuels by 2030 than would be consistent with keeping warming to less than 1.5 degree Celsius – and 85% of that expansion is slated to come from the United States and Canada. The announced policy, known formally as the  , won’t curtail this emissions growth.

“The point of conducting thorough environmental assessments is to ensure we have the best information available to make decisions that are good for people in Canada,” said Levin. “Instead, the government has created a policy full of loopholes that polluters can exploit. How can we make responsible decisions as a country if we’re not even willing to ensure we have all the right information?”

As advanced by Environmental Defence and allies, a strong climate test would:

  • ensure that Canada’s new infrastructure be compatible with a low carbon future;
  • discourage investment in projects that would become stranded assets as world markets increasingly move away from oil and gas;
  • provide a clear and accountable set of climate guidelines for companies, communities, review panels and the public;
  • account for the significant downstream emissions from oil, natural gas and coal that is mined in Canada but exported to other countries, thereby recognizing the global nature of climate change and Canada’s contribution to it. Research shows that the total amount of greenhouse emissions from Canada’s exports of fossil fuels is greater than all emissions that occur within Canada

Though an improvement from the draft version of the policy – now project proponents will need to submit net-zero emission plans for projects that go beyond 2050 – the policy released today does not ensure any of the above goals. It punts requirements for emissions reductions well into the future rather than ensuring Canada is on the right path to do its fair share over the next decade to avoid catastrophic climate change.

As a result, Canadians should not expect that future assessments will do a better job of ensuring new projects are consistent with international climate commitments. Projects currently being considered include a proposed LNG pipeline in Quebec (Gazoduq) – which in conjunction with the Énergie Saguenay LNG plant would produce 7.8 million tons of greenhouse gas annually – and the huge expansion of a tar sands mine by Suncor Energy which would produce another 3 million tons of carbon pollution each year.

“Just a few months ago, Teck Resources made the surprising decision to withdraw their own application for a new tar sands mine. Their reason? A lack of a framework that reconciles oil and gas development decisions with climate action,” added Levin. “And yet the government seems not to have learned its lesson and has declined to show bold leadership. Canadians needed this policy to guide industry towards projects that are compatible with a safe and healthy future. Instead, communities will be forced to continue fighting to ensure that life cycle greenhouse gas emissions are adequately included in the impact reviews of new projects.”

Canada continues to lag behind on real climate leadership. The plan unveiled in the United States by the Biden-Bernie Sanders Unity Task Force includes a commitment to implementing a climate test.

Julia Levin 

Climate & Energy Program Manager 

Pronouns: she/her

Written by Stephen Rees

July 16, 2020 at 5:03 pm

Tlaamin Elder’s Beautiful Digital Gift

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In today’s Tyee is an article that I want to quote

“Paul declined to be interviewed for this article, simply because she felt she had already said enough. That’s hard to argue with given how filled the book is with her knowledge. And the wisdom of an Elder is something to be respected, too. Knowing when to start talking and when to stop is a teaching a lot of us could use.”

I had hoped that I had learned that. In so far as this blog is concerned, there is much less new being added as I feel that I have covered the ground I originally intended adequately already. The “Paul” who declined to be interviewed is the author of As I Remember It: Teachings (Ɂəms tɑɁɑw) from the Life of a Sliammon Elder, is Elsie Paul, – which is a book I got from Vancouver Public Library in part because of our trip to the Sunshine Coast. The article is actually about a web site based on the material in that book – go read it to find the link to that!

The other thing that I think also bears your attention right now is “Covid, Twitter, and Critique” which is published in American Anthropologist and deals with what we needed to have been learning from the pandemic.

The anthropologist is Carlo Caduff of King’s College, London who says

“I had not been using Twitter much before the pandemic. During this period, I have turned to it as a kind of public notebook, where I could write down thoughts and then publish them and have a record for myself. The tweets were either orientations, diagnostic, or suggestions for another politics of life.”

“At the beginning of the pandemic there was hardly any political voice, because people were overwhelmed, and then stuck. Many were busy with homeschooling. And then lots of people were scared, so the first responses were either people not saying much, or they were repeating what everyone else was saying, or it was just silence.

Now, I think that has definitely changed. There are more political voices. The views are more diverse. People have gained a better sense of the complexity and the seriousness of the pandemic response and its consequences.”

“The lockdown was presented as if there were no alternatives. And that’s simply not true. First of all, you need to understand the history of the idea of the lockdown. Lockdowns only figured in infectious disease modeling. They were basically a theoretical idea that disease modelers used in simulations: What happens if you do this? What happens if you do that? Can you reduce the number of deaths if you do x, y, z? A complete shutdown was never an option that public health professionals considered in their preparedness plans for a pandemic like this.”

The parallel is the Perfect Competition market – which economists always knew did not exist either but was also a theoretical idea – a simplified abstraction meant to help explain how markets in general would work if viewed without the inescapable complexities of real life. It was never supposed to normative or prescriptive. Unfortunately most politicians never got beyond Economics 101 even if they did study it academically. A bit like putting a new graduate from high school with an A in physics in charge of a nuclear reactor.

I have been keeping a journal during the pandemic but it does not cover anything that can be found in the on line universe. It exists only as some paper notebooks – three so far – written with a fountain pen. Because an archivist that I knew from Facebook said that in the future our electronic ruminations may well not be readable. The technology will certainly have moved on – or maybe be even eliminated – whereas physical marks with permanent ink on good quality acid free paper lasts quite a while in the right circumstances. One thing I do know is that I was completely unaware at the time that lockdowns were only theoretical until now. So we truly are living through an experiment, so maybe my recording first person experience will have value freed from the certainties that seem to infest both social and mainstream media.

Written by Stephen Rees

July 3, 2020 at 3:43 pm

The Notebook

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A while ago now, I used to teach adults about energy efficiency. One such venture was concerned with buildings. The students were learning to qualify for a national program, based in the United States, and I travelled to Bellingham as a guest speaker. Nearly everyone else they heard would have been talking about building issues – insulation and so on. Hardware mostly, but also management. I talked about the bigger picture. How a building’s use and location was actually much more significant in terms of its greenhouse gas footprint than the energy used by its HVAC system.

The consulting company that ran the course gave me a nice little memento. The notebook, which was part of the kit given to the students. It is a monument to the principles that were being taught. The cover is made from recycled tyres. The paper, of course, was recycled too – every page has a pale grey logo printed on it.

The pages are all punched and the binding is by four small openable rings. Towards the end of the book there is page printed with the contact information of the maker. So that users can order a refill. Today I contacted them by email as, when I went to their web page, I could not find a refill that would fit this format.

Their reply. “Yes, this is a long discontinued item and we do not carry these refills anymore.
I am sorry about it.”

I won’t embarrass them by publishing their name. It is just a sad reality that business is business, and clearly this product, designed to be reusable for much longer than any one pad of paper might be, was not a commercial success. Which says more about us than them.

Written by Stephen Rees

July 1, 2020 at 11:52 am

Posted in Recycling

I have now left Facebook

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I clicked on that blue button on the bottom left of that screenshot. Nothing happened. I did not get any kind of confirmation. What is supposed to happen – according to Facebook is “Enter your password, click Continue and then click Delete Account.” but I didn’t get to that page where I can do that.

This blog started to get neglected as Twitter and Facebook began to get much more attention. But I increasingly got more concerned about the direction that Facebook was taking. Not the people I was following or the ones who followed me (and those were easy enough to quietly ignore when necessary). More disconcerting was the attitude of Mark Zuckerberg as described in this Mother Jones article.

I did contact Facebook help and, of course, I didn’t get any.

So I have now removed the Social Media widgets from the right hand column, and I have also deleted Facebook, Instagram (which is owned by Facebook) and Messenger from all my devices. When you are on a “service” which is “free”, you are the product. So simply saying you are not going to patronize the advertisers doesn’t actually change anything. Facebook still gets revenue for serving you the ad. Only by leaving Facebook can you change anything – but the first thing is that you will not any longer be going down that rabbit hole. If you miss the people you used to enjoy seeing posts from, there are other ways that you can contact them. And all the rest was fluff anyway.

UPDATE June 16

I am pleased to report that I have found a solution. I had installed a Facebook app called “Fluff Busting Purity” which ran as an extension on Chrome. Simply removing that enabled me to get to the account deletion. But then I discovered that the password – as recorded by Chrome – did not work. So I changed the password then deleted. I now have 30 days before the account finally disappears.

Written by Stephen Rees

June 7, 2020 at 4:18 pm

Posted in Transportation

I don’t know right now

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Every so often when I look away from this screen to look out of the window, I am struck by the fact that what I am looking at is three dimensional. A screen, of course, isn’t. Though there are increasingly frequent images which try to get around this.

I looked away because I had just read Elizabeth Warren’s experience of dealing with one of her brother’s death from COVID-19. I do not know her, of course. I just know of her. Of her relationship to her brothers, not at all. Until now. And, for reasons that I am at a loss to explain, this one hit home. Hard.

And she is right. It did not have to happen like this.

Written by Stephen Rees

May 17, 2020 at 5:26 pm

Posted in personal thoughts

The Pixsy Experience

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Lens cleaning cloth from Pixsy
Free gift of a lens cleaning cloth to celebrate getting paid!

As a PRO member of flickr (something I pay for) I get a complimentary subscription to Pixsy a service which matches pictures online. It is used to track copyright violations. Some people copyright everything they post online. Other use a Creative Commons license which attempts to restrict some of the uses pictures are put to.

At one time I was posting my pictures directly to this blog – now I try to post only links to my flickr photostream – as everything that is on this blog is covered by my copyright notice. But of course I also use plenty of illustrations from other people. I regret that I was not always as careful as I should have been over identifying the source of the images I used. So in using Pixsy I have discovered not just those pictures that others have used, but also pictures that I should have labelled.


In an attempt to speed up the effectiveness of my use of Pixsy I have now removed this blog as a match in the hopes of removing a lot of duplicates. It would also be nice if I could have got rid of a lot of old matches when I was not bothering dealing with on Pixsy. Unfortunately that still leaves me with a 2,363 matches – or which 2,266 “unseen” that need to marked ignore, approved use or not my image or followed up – send takedown or submit case.

Pixsy also identifies domains that are “not viable for commercial resolution” or those outside jurisdictions that they support . You can send them a takedown notice – which in my experience has been completely futile – although the number of those you can send through Pixsy is also limited. It is also pointless pursuing sites which are simply hotlinking back to another site which hosts the image. In that case you have to go after the not site but the host – which again usually means a takedown – but I have had some success with removing my images from such sites. Not so much in the way of reward for use of course. What is annoying is that it too often takes me time to fill in the necessary details, file a claim and then have it rejected because is in the wrong jurisdiction. It would be far better if their software detected that and did not waste so much of my time.

In fact so far in the course of three years, I have actually been paid three times. Not enormous sums, but worth some effort. Since I only get 1,000 images monitored on my free plan and on flickr alone I have 18,439 images I do want to get rid of the useless ones even if that does take a lot of time. Comparing what I would have to pay every month to upgrade with how much I have been paid in the last three years, I find it hard to justify an upgrade.

There are also many images on my photostream that are very similar to those of others. After most of the places I have visited are now highly accessible and – before COVID19 – everybody now travels and carries a camera or smartphone and often both. So lots of people post pictures that are remarkably similar. Good luck if you can actually demonstrate that your photo of the front elevation of Sacre Coeur is unique – and anyway France is one of those jurisdictions where Pixsy has given up altogether.

But the Good News there are sites which do indeed use my images but comply with the strictures of the Creative Commons license and get the Approved sticker!

POSTSCRIPT

I have also come across sites that go to great lengths to make sure they do not have to respond to DCMA takedown notices. Since these are commercial operations, that go to great efforts to avoid their responsibilities to people whose work they exploit, you have to wonder how they treat their customers. I would not want to spend my money on the services or products of those who have demonstrated such determination to avoid the consequences of their actions.

Written by Stephen Rees

April 23, 2020 at 6:21 pm

Posted in photography

Tagged with

Promising new approach

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Elsewhere the orange idiot is pushing drugs that have not been proven safe or effective. The following press release arrived in my in box this morning, and may not be noticed by our mainstream media because they are busy cutting staff pay – or even shutting down altogether. The idea that the government – or their readers – should now ride to their rescue seems really strange to me since the reason they have nothing to fall back on is that they have been bleeding the companies dry. I have no sympathy whatever for these vultures.

Queen’s University leading cell therapy clinical trial to help improve outcomes in COVID-19 patients

Researchers at Queen’s University Belfast are leading a UK-wide clinical trial, offering an innovative cell therapy treatment for COVID-19 patients with acute respiratory failure.

This clinical trial, led by Professor Danny McAuley and Professor Cecilia O’Kane, both researchers from the Wellcome-Wolfson Institute for Experimental Medicine at Queen’s, is investigating the use of allogenic Mesenchymal stromal cells (MSCs) in patients with a complication known as Acute Respiratory Distress Syndrome (ARDS) caused by COVID-19.

In the most critically unwell patients with COVID-19, many develop a complication known as ARDS. In ARDS the lungs become inflamed and leaky so they fill with fluid. This causes respiratory failure and patients may require admission to intensive care and a ventilator machine to support their breathing.

A recent statement from the four UK Chief Medical Officers outlined the importance of clinical trials amidst the COVID-19 crisis. Professor Cecilia O’Kane said: “It is only through clinical trials we will be able to determine if new treatments are effective and safe in critically ill patients.”

The trial involves the use of MSCs, a type of cell derived from human tissue such as bone marrow or umbilical cord (which is otherwise discarded after the baby is born), to treat the injury to the lung caused by COVID 19. MSCs are a novel treatment that have been shown in experimental models to reduce inflammation, fight infection and improve the repair of injured tissue.

Patients in this trial, which is known as REALIST COVID 19, will be treated with a purified population of MSCs derived from umbilical cord tissue called ORBCEL-C. The ORBCEL-C therapy has been developed by scientists at Orbsen Therapeutics in Galway, Ireland. The ORBCEL-C therapeutic is manufactured under licence by the UK NHS Blood and Transplant Service for the REALIST COVID-19 trial.

The trial is being introduced as part of an existing programme of research investigating the use of MSCs in patients with ARDS. The first patient has now been recruited with plans to recruit at least 60 patients throughout the COVID-19 pandemic at multiple sites across the UK including Belfast, Birmingham and London.

Professor Ian Young, Clinical Professor at the Centre for Public Health, Queen’s University Belfast, Director of HSC R&D and Chief Scientific Advisor at the Department of Health, said: “The Health and Social Care Research & Development Division has been working with researchers across HSC to address the global problem of Coronavirus.  We have contributed £230K for this vital research which will provide important evidence regarding a potential new treatment for respiratory failure, a leading cause of mortality in COVID-19.  We will continue to support health research and encourage people to participate in research trials and other studies so patients can get the best possible treatment to help tackle the spread of COVID-19.”

The trial has been identified by the National Institute for Health Research (NIHR) as a national urgent public health study. It is one of a number of COVID-19 studies that have been given urgent public health research status by the Chief Medical Officer/ Deputy Chief Medical Officer for England.  The study is funded by the Health and Social Care Research & Development Division and the Wellcome Trust, sponsored by the Belfast Health and Social Care Trust and supported by the NI Clinical Trials Unit, the NIHR Clinical Research Network and the Northern Ireland Clinical Research Network.

Orbsen CSO Steve Elliman noted: “While there are over 100 vaccines and therapies in development targeting the SARS-CoV-2 infection – at present there are no disease modifying therapies approved for ARDS.  We’re delighted the REALIST trial was approved and listed by NIHR as an Urgent Public Health Research Study so we can continue assess the safety of the ORBCEL-C therapy in patients with ARDS.”

Sir Professor Alimuddin Zumla of University College London, a global coronavirus and infectious diseases expert said: “This is an exciting and important trial which targets rectifying the underlying causes of lung damage and has great potential of saving many lives from COVID-19. The team should be congratulated for their leadership of host-directed therapies, a concept which has not yet been explored to its full potential.”

Professor Danny McAuley is also part of an international network of researchers who are taking forward trials of umbilical cord-derived Mesenchymal stromal cells for the treatment of COVID-19: UK: (UCL- Sir Professor Azumla); Portugal (Champualimud Foundation – Professor Markus Maurer; Italy (INMI-Professor Giuseppe Ippolito) and China (Fifth Medical Center- Professor Fu-Sheng Wang.)

-Ends-

  1. Media inquiries to comms.officer@qub.ac.uk  
  2. About NIHR: Please visit  https://www.nihr.ac.uk/covid-19/ to learn about other studies that have been given urgent public health status and the single, national prioritisation process that has been established to prevent duplication of effort and to ensure that the resources and capacity of the health and care system to support COVID-19 research are not exceeded.
  3. About Wellcome: Wellcome exists to improve health by helping great ideas to thrive. We support researchers, we take on big health challenges, we campaign for better science, and we help everyone get involved with science and health research. We are a politically and financially independent foundation. For more information please  visit: http://wellcome.ac.uk/
  4. For further information about HSC Research & Development Division work, please visit: www.research.hscni.net

Written by Stephen Rees

April 7, 2020 at 10:00 am

Posted in good news, Pandemic

Tagged with